Human CD38 and related molecules

Cover of: Human CD38 and related molecules |

Published by Karger in Basel .

Written in English

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Subjects:

  • CD antigens

Edition Notes

Book details

Statementvolume editors Kapil Mehta, Fabio Malavasi.
SeriesChemical immunology ;, vol. 75
ContributionsMehta, Kapil., Malavasi, Fabio.
Classifications
LC ClassificationsQR186.6.C42 H85 2000
The Physical Object
Paginationxii, 281 p. :
Number of Pages281
ID Numbers
Open LibraryOL6805016M
ISBN 103805569238
LC Control Number00267829
OCLC/WorldCa43629245

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Human CD38 and Related Molecules. Book August is a human CDspecific IgG1 antibody that is in clinical development for the treatment of multiple myeloma (MM). ISBN: OCLC Number: Description: xii, pages: illustrations (some color) ; 25 cm. Contents: The making of leukocyte receptor: origin, genes and regulation of.

Recent reports have suggested an association of CD38 in diverse human pathologies such as HIV, chronic B lymphocytic leukemia, myeloma, lymphoma, diabetes, and retinoic acid syndrome.

This book. Human CD38 and related molecules. [K Mehta;] Home. WorldCat Home About WorldCat Help. Search. Search for Library Items Search for Lists Search for Contacts Search for a Library. Create (Produktform)Electronic book. Find many great new & used options and get the best deals for Human CD38 and Related Molecules by Mehta, Kapil at the best online prices at eBay.

Free shipping for many products. Request PDF | Schematic Portrait of Human CD38 and Related Molecules | Finally, a summary of the main characteristics of the CDB8 molecule are outlined in figure 7. | Find, read and cite all the.

Now, immune molecules, CD38 and CD, are the immuno-neuronal molecules which also regulate neuronal function. Because functional roles of CD in the intestinal tissue were reported in [], Cited by: 1. Reduced plasma oxytocin and both oxytocin receptor and CD38 risk alleles were related to less parental touch; CD38 gene polymorphism is associated Human CD38 and related molecules book chronic lymphocytic leukemia.

Human CD38 is the mammalian prototype of a family of proteins which share structural similarities and an ectoenzymatic activity involved in the production of calcium mobilizing compounds.

Besides the Cited by: CD38 (cluster of differentiation 38), also known as cyclic ADP ribose hydrolase is a glycoprotein found on the surface of many immune cells (white blood cells), including CD4 +, CD8 +, B lymphocytes and Aliases: CD38, Human CD38 and related molecules book, ADPRC 1, CD38 molecule.

The link between CD38/CD and human diseases will be explored here in the context of chronic lymphocytic leukemia, myeloma and ovarian carcinoma, although other disease associations are also Cited by: Background: CD CD38, also known as ADP-ribosyl cyclase, is a Type II integral membrane protein.

The enzyme is able to transform NAD(P) + into three different products with calcium mobilizing ability. The extracellular domain of human CD38 (amino acid residues 45–) is expressed as a fusion protein with a maltose-binding protein (MBP-CD38, M r of 70,).

18 Human CD38 cDNA covering the. CD38 is a multifunctional protein widely expressed in cells from the immune system and as a soluble form in biological fluids. CD38 expression is up-regulated by an array of inflammatory mediators, and it is Author: Estibaliz Glaría, Annabel F.

Valledor. human protein atlas information i The Tissue Atlas contains information regarding the expression profiles of human genes both on the mRNA and protein level. The protein expression data from 44 normal. 10 Key Points to form Human Molecules 1.

A male and female pair unite their hearts through the Soul to form a Human Atom 2. Pure motives and Soul Contact will be at the heart of every Human Atom to. Human CD38 is an ectoenzyme expressed on the surface of B-cells that makes cyclic-ADP-ribose (cADPR) and ADP-ribose from NAD+ (nicotinamide diphosphate ribose, oxidized form).

The Cited by: CD38 is a signaling molecule in B-cell chronic lymphocytic leukemia cells. Deaglio S, Capobianco A, Bergui L, Durig J, Morabito F, Duhrsen U, Malavasi F. Blood. Sep 15;(6) Epub. Function.

CD38 is a multifunctional ectoenzyme that catalyzes the synthesis and hydrolysis of cyclic ADP-ribose (cADPR) from NAD + to reaction products are essential for the. Our CD38 Peptides and CD38 Proteins can be used in a variety of model species: Human.

Use the list below to choose the CD38 Peptide and CD38 Protein which is most appropriate for your research. There are no reviews for CD38 Recombinant Protein (NBP). By submitting a review you will receive an Amazon e-Gift Card or Novus Product Discount.

Review with no image -- $10/€7/£6/$10. CD Marker Handbook Human CD Markers CD Alternative Name Ligands & Associated Molecules T Cell B Cell Dendritic Cell NK Cell Stem Cell/Precursor Macrophage/Monocyte Granulocyte Platelet File Size: 2MB.

signal transduction and calcium signaling. CD38 has been used as a prognostic marker in leukemia. It can also be used to identify plasma cells. References H, et al.

() CD molecules. The relationship between CD38 expression on activated germinal center (GC) cells and mature differentiated B cells was studied in the mouse.

CD38 is expressed on follicular cells in the Author: A. Oliver, J. Keaniey. Fig 1: Human CD38 Recombinant Protein (Fc Tag) Roll over image to zoom in. The conclusions derived from the biochemical analysis of the molecule were independently confirmed by cloning of a cDNA for human CD38 in [3].

On the basis of its expression and allocation among Cited by: 3. CD38 has been used as a prognostic marker in leukemia. It can also be used to identify plasma cells. References H, et al. () CD molecules human cell differentiation molecules. Human CD38, a leukocyte receptor and ectoenzyme, is a member of a novel eukaryotic gene family of nicotinamide adenine dinucleotide-converting enzymes: extensive structural homology with the genes Cited by: 8.

"The Human Molecule" covers a fundamental change in our perception of the human being which should it prove to be true, rival Darwin's "On the Origin of Species". Thims puts forth the /5(5). Expression of CD38 in cancer tissue.

The cancer tissue page shows antibody staining of the protein in 20 different cancers. This is a list of therapeutic, diagnostic and preventive monoclonal antibodies, antibodies that are clones of a single parent used as drugs, the International Nonproprietary Names (INNs) end in -mab.

The anti-CD38 monoclonal antibody, daratumumab, is well tolerated and has high single agent activity. In the 16 mg/kg cohort of the GEN study, at least a partial response (PR) was Cited by: Description. CD11b is a kD type I transmembrane glycoprotein also known as α M integrin, Mac-1, CR3, and C3biR.

CD11b non-covalently associates with integrin β 2 (CD18) and is expressed on /5(4). Human Cell Differentiation Molecules is an organisation which runs HLDA (Human Leucocyte Differentiation Antigens) Workshops and names and characterises CD molecules.

New CD Molecules. CD38, also known as ADP­ribosyl cyclase, is a Type II integral membrane protein. The enzyme is able to transform NAD(P)+ into three different products with calcium mobilizing ability, cyclic ADP­ribose.

The structure of the CD38 molecule has been evaluated by one- and two-dimensional gel analysis and by enzymatic digestions. The source of the Ag was mainly membrane preparations obtained from MLC Cited by: CD38 is a type II glycoprotein that acts both as a bifunctional enzyme, responsible for the synthesis and hydrolysis of cyclic ADP‐ribose, and as a signal‐transducing surface receptor.

Although CD Nicotinamide adenine dinucleotide (NAD) is increasingly recognized as an important signaling molecule that affects numerous biological pathways. Thus, enzymes that metabolize NAD can have important Cited by: The first full-length book on the history and development of the concept of the human molecule, with focus on its mechanistic function in the year old science of human chemistry, the study of.

F8: Figure 8. Biochemical activity of the CD38/CDa/CD73 pathway in Jurkat T cells upon activation or transgene-driven CD73 expression.

Extracellular NAD+ is metabolized by the nicotinamide adenine. CD38 via formation of protein/lipid domains to which signaling-competent molecules, such as immunorecep-tor tyrosine-based activation motif-bearing CD3 mole-cules and protein-tyrosine .regulation of cd38 expression in human airway smooth muscle (hasm) cells a thesis submitted to the faculty of the graduate school of the university of minnesota by joseph antony jude in partial fulfillment .CD38 is highly and ubiquitously expressed on MM cells and at low levels on normal lymphoid and myeloid cells.

13 CD38 is a transmembrane glycoprotein with ectoenzymatic activity in the catabolism Cited by:

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